PrecisionLife_DecodeME Gene-Tissue Expression and Enrichment Report

Run Configuration

RUN_NAMEPrecisionLife_DecodeME
K_VALUES5 13
STAT_METHODmedian
Z_FLAG--z-score
SORT_FLAGNone

Report Thresholds

FDR Cutoff0.05
Enrichr Combined Score Min10
Max Terms per Category5
Max Tissues Shown5
Max Genes Shown20

Table of Contents

Global Files: Expression Matrix Clustering Metrics STRING Terms Enrichr Terms

Clustering with k = 5

Resolution Visualizations (k=5)

Global Heatmap Silhouette Analysis Plot Cluster Assignments (CSV) Gene Silhouette Scores (CSV)

Cluster 1 (k=5)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 45 genes.
Average Silhouette Score: 0.271.
Highest expression is observed in: Brain - Cerebellar Hemisphere, Brain - Cerebellum, Brain - Frontal Cortex (BA9), Brain - Cortex, Brain - Anterior cingulate cortex (BA24).
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Synapse (GOCC:0045202) (FDR: 0.004); Asymmetric synapse (GOCC:0032279) (FDR: 0.006); Postsynapse (GOCC:0098794) (FDR: 0.009); Axon (GOCC:0030424) (FDR: 0.016); Postsynaptic density (GOCC:0014069) (FDR: 0.034) ... *(Total significant: 6. See string_terms.csv for full list.)*
- Component: Synapse (GO:0045202) (FDR: 0.014); Neuron to neuron synapse (GO:0098984) (FDR: 0.017); Cell junction (GO:0030054) (FDR: 0.030); Intrinsic component of membrane (GO:0031224) (FDR: 0.040); Asymmetric synapse (GO:0032279) (FDR: 0.040) ... *(Total significant: 10. See string_terms.csv for full list.)*
- Function: Gated channel activity (GO:0022836) (FDR: 0.005); Ion channel activity (GO:0005216) (FDR: 0.016); Glutamate receptor activity (GO:0008066) (FDR: 0.038); Inorganic molecular entity transmembrane transporter activity (GO:0015318) (FDR: 0.038) *(Total significant: 4)*
- TISSUES: Brain (BTO:0000142) (FDR: 1.77e-05); Hippocampus (BTO:0000601) (FDR: 2.10e-04); Cerebral hemisphere (BTO:0000231) (FDR: 6.90e-04); Forebrain (BTO:0000478) (FDR: 0.002); Cerebral cortex (BTO:0000233) (FDR: 0.009) ... *(Total significant: 6. See string_terms.csv for full list.)*
- DISEASES: Cerebellar disease (DOID:2786) (FDR: 0.045) *(Total significant: 1)*
- Keyword: Alternative splicing (KW-0025) (FDR: 8.50e-04); Membrane (KW-0472) (FDR: 0.031); Ion channel (KW-0407) (FDR: 0.032); Glycoprotein (KW-0325) (FDR: 0.037); Transmembrane helix (KW-1133) (FDR: 0.037) *(Total significant: 5)*
- KEGG: Glutamatergic synapse (hsa04724) (FDR: 0.035); Nicotine addiction (hsa05033) (FDR: 0.035) *(Total significant: 2)*
- PMID: (2008) Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify connectivity constellation and drug target genes with pleiotropic effects. (PMID:18991966) (FDR: 0.042); (2015) Human cell adhesion molecules: annotated functional subtypes and overrepresentation of addiction-associated genes. (PMID:25988664) (FDR: 0.042); (2013) Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants. (PMID:23728934) (FDR: 0.042) *(Total significant: 3)*
- HPO: Temporal measurement (EFO:0000719) (FDR: 3.78e-09); Respiratory disease biomarker (EFO:0006841) (FDR: 1.24e-08); Cytokine measurement (EFO:0004873) (FDR: 8.01e-08); Cognition (EFO:0003925) (FDR: 8.52e-08); Protein measurement (EFO:0004747) (FDR: 6.32e-07) ... *(Total significant: 88. See string_terms.csv for full list.)*
- NetworkNeighborAL: Postsynaptic cell membrane, and Protein-protein interactions at synapses (CL:22977) (FDR: 3.10e-04); Transmitter-gated channel activity, and Neurexins and neuroligins (CL:22978) (FDR: 0.015) *(Total significant: 2)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Regulation of Trans-Synaptic Signaling (GO:0099177) (Adj. P: 7.58e-04, Combined Score: 564.85); Negative Regulation of Endopeptidase Activity (GO:0010951) (Adj. P: 0.017, Combined Score: 387.24); Regulation of Endopeptidase Activity (GO:0052548) (Adj. P: 0.017, Combined Score: 360.35); Regulation of Potassium Ion Transmembrane Transport (GO:1901379) (Adj. P: 0.006, Combined Score: 354.46); Heparan Sulfate Proteoglycan Metabolic Process (GO:0030201) (Adj. P: 0.017, Combined Score: 315.36) ... *(Total significant: 30. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Glutamate-Gated Calcium Ion Channel Activity (GO:0022849) (Adj. P: 0.005, Combined Score: 2207.09); Ligand-Gated Monoatomic Ion Channel Activity Involved in Regulation of Presynaptic Membrane Potential (GO:0099507) (Adj. P: 0.005, Combined Score: 976.58); Metalloendopeptidase Inhibitor Activity (GO:0008191) (Adj. P: 0.006, Combined Score: 664.11); Heparan Sulfate Sulfotransferase Activity (GO:0034483) (Adj. P: 0.006, Combined Score: 596.93); Glutamate-Gated Receptor Activity (GO:0004970) (Adj. P: 0.006, Combined Score: 493.47) ... *(Total significant: 23. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Catenin Complex (GO:0016342) (Adj. P: 0.025, Combined Score: 225.26); Ionotropic Glutamate Receptor Complex (GO:0008328) (Adj. P: 0.028, Combined Score: 171.78); Potassium Channel Complex (GO:0034705) (Adj. P: 0.025, Combined Score: 111.26); Postsynaptic Density Membrane (GO:0098839) (Adj. P: 0.034, Combined Score: 108.96); Glutamatergic Synapse (GO:0098978) (Adj. P: 0.025, Combined Score: 92.55) ... *(Total significant: 10. See enrichr_terms.csv for full list.)*
- Reactome_2022: Synaptic Adhesion-Like Molecules R-HSA-8849932 (Adj. P: 0.032, Combined Score: 336.56); HS-GAG Biosynthesis R-HSA-2022928 (Adj. P: 0.043, Combined Score: 204.59); Protein-protein Interactions At Synapses R-HSA-6794362 (Adj. P: 0.032, Combined Score: 114.98); Neuronal System R-HSA-112316 (Adj. P: 0.020, Combined Score: 66.95); Transmission Across Chemical Synapses R-HSA-112315 (Adj. P: 0.043, Combined Score: 48.49) *(Total significant: 5)*
- Human_Phenotype_Ontology: Incomplete penetrance (HP:0003829) (Adj. P: 0.019, Combined Score: 204.50) *(Total significant: 1)*
- OMIM_Disease: ataxia (Adj. P: 0.032, Combined Score: 76.91) *(Total significant: 1)*

Top Genes (by silhouette):

RGS7 (sil: 0.45), CTNNA2 (sil: 0.44), SEZ6L (sil: 0.44), ATCAY (sil: 0.44), MYT1L (sil: 0.43), HS3ST4 (sil: 0.41), GRIK1 (sil: 0.40), SLC35F3 (sil: 0.39), GABRB1 (sil: 0.39), ANKS1B (sil: 0.38), SLC39A12 (sil: 0.37), CSMD1 (sil: 0.37), CACNA1A (sil: 0.37), DISP2 (sil: 0.36), NOS1AP (sil: 0.36), KCNIP4 (sil: 0.36), RBFOX1 (sil: 0.36), GRIA1 (sil: 0.35), GRM7 (sil: 0.35), SPOCK3 (sil: 0.35) ...

Cluster 2 (k=5)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 66 genes.
Average Silhouette Score: -0.052.
Highest expression is observed in: Cells - EBV-transformed lymphocytes, Cells - Cultured fibroblasts, Brain - Cerebellar Hemisphere, Brain - Cerebellum, Brain - Frontal Cortex (BA9).
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Sarcolemma (GOCC:0042383) (FDR: 0.010) *(Total significant: 1)*
- Component: Sarcolemma (GO:0042383) (FDR: 0.014) *(Total significant: 1)*
- WikiPathways: Cell-type dependent selectivity of CCK2R signaling (WP3679) (FDR: 0.015) *(Total significant: 1)*
- HPO: Mental or behavioural disorder biomarker (EFO:0006848) (FDR: 6.03e-18); Temporal measurement (EFO:0000719) (FDR: 3.76e-09); Protein measurement (EFO:0004747) (FDR: 1.10e-07); Mathematical ability (EFO:0004875) (FDR: 7.72e-07); Self reported educational attainment (EFO:0004784) (FDR: 1.48e-06) ... *(Total significant: 64. See string_terms.csv for full list.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Cellular Response to Caffeine (GO:0071313) (Adj. P: 0.022, Combined Score: 1361.38); Release of Sequestered Calcium Ion Into Cytosol by Sarcoplasmic Reticulum (GO:0014808) (Adj. P: 0.022, Combined Score: 1361.38); Response to Caffeine (GO:0031000) (Adj. P: 0.022, Combined Score: 1361.38); Release of Sequestered Calcium Ion Into Cytosol by Endoplasmic Reticulum (GO:1903514) (Adj. P: 0.024, Combined Score: 843.15); Cellular Response to Purine-Containing Compound (GO:0071415) (Adj. P: 0.024, Combined Score: 843.15) ... *(Total significant: 9. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Neurotrophin Binding (GO:0043121) (Adj. P: 0.022, Combined Score: 1047.40); Intracellularly Ligand-Gated Monoatomic Ion Channel Activity (GO:0005217) (Adj. P: 0.035, Combined Score: 452.93); Intracellularly Gated Calcium Channel Activity (GO:0015278) (Adj. P: 0.037, Combined Score: 326.43); Ligand-Gated Calcium Channel Activity (GO:0099604) (Adj. P: 0.040, Combined Score: 250.79) *(Total significant: 4)*
- GO_Cellular_Component_2025: Smooth Endoplasmic Reticulum (GO:0005790) (Adj. P: 0.048, Combined Score: 232.03); Calcium Channel Complex (GO:0034704) (Adj. P: 0.027, Combined Score: 145.13); Sarcolemma (GO:0042383) (Adj. P: 0.027, Combined Score: 141.06) *(Total significant: 3)*

Top Genes (by silhouette):

ZNF423 (sil: 0.11), DENND2A (sil: 0.10), FTO (sil: 0.10), CELF2 (sil: 0.08), ASB3 (sil: 0.07), RB1CC1 (sil: 0.06), CNTN4 (sil: 0.06), TMEM132C (sil: 0.05), AFF3 (sil: 0.05), CCDC149 (sil: 0.04), SUB1 (sil: 0.03), YWHAB (sil: 0.02), RASGRF2 (sil: 0.02), PKM (sil: 0.02), DDR1 (sil: 0.02), PIGX (sil: 0.01), GALNT18 (sil: 0.01), FAM172A (sil: 0.01), SFMBT2 (sil: 0.01), BTBD2 (sil: 0.01) ...

Cluster 3 (k=5)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 85 genes.
Average Silhouette Score: 0.232.
Highest expression is observed in: Cells - Cultured fibroblasts, Fallopian Tube, Thyroid, Adipose - Visceral (Omentum), Nerve - Tibial.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- Keyword: Phosphoprotein (KW-0597) (FDR: 0.048); Repeat (KW-0677) (FDR: 0.048) *(Total significant: 2)*
- HPO: Body weights and measures (EFO:0004324) (FDR: 4.80e-06); Everted lower lip vermilion (HP:0000232) (FDR: 9.01e-05); Eye disease (EFO:0003966) (FDR: 1.80e-04); Body height (EFO:0004339) (FDR: 1.80e-04); Mental or behavioural disorder biomarker (EFO:0006848) (FDR: 1.80e-04) ... *(Total significant: 69. See string_terms.csv for full list.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- Reactome_2022: NR1H3 And NR1H2 Regulate Gene Expression Linked To Cholesterol Transport And Efflux R-HSA-9029569 (Adj. P: 0.005, Combined Score: 338.59); NR1H2 And NR1H3-mediated Signaling R-HSA-9024446 (Adj. P: 0.006, Combined Score: 234.79) *(Total significant: 2)*
- OMIM_Disease: macular degeneration (Adj. P: 0.016, Combined Score: 178.23) *(Total significant: 1)*

Top Genes (by silhouette):

BTBD7 (sil: 0.40), SEC23IP (sil: 0.39), CYFIP1 (sil: 0.37), ZC3H7A (sil: 0.36), SLC25A24 (sil: 0.35), ZZEF1 (sil: 0.35), EHMT1 (sil: 0.34), ZNF282 (sil: 0.34), USP47 (sil: 0.34), AFF1 (sil: 0.33), SCAMP3 (sil: 0.32), NOP9 (sil: 0.32), LOXL2 (sil: 0.31), KANSL1 (sil: 0.31), UTRN (sil: 0.31), UGGT1 (sil: 0.31), MED13L (sil: 0.31), MAML2 (sil: 0.31), ADAMTS2 (sil: 0.31), CYB5RL (sil: 0.31) ...

Cluster 4 (k=5)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 12 genes.
Average Silhouette Score: 0.704.
Highest expression is observed in: Testis, Kidney - Medulla, Pancreas, Brain - Spinal cord (cervical c-1), Stomach.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- NetworkNeighborAL: Mixed, incl. Protein of unknown function DUF4659, and piRNA binding (CL:35645) (FDR: 0.043) *(Total significant: 1)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- Reactome_2022: Expression And Translocation Of Olfactory Receptors R-HSA-9752946 (Adj. P: 0.035, Combined Score: 38.12); Olfactory Signaling Pathway R-HSA-381753 (Adj. P: 0.035, Combined Score: 36.97) *(Total significant: 2)*

Top Genes (by silhouette):

OR5V1 (sil: 0.81), OR5AC2 (sil: 0.81), C18orf63 (sil: 0.81), C20orf173 (sil: 0.81), ACTL8 (sil: 0.79), LRRC74A (sil: 0.79), C5orf47 (sil: 0.76), C4orf45 (sil: 0.72), EFCAB5 (sil: 0.63), ZSCAN5C (sil: 0.62), ZPLD1 (sil: 0.46), PPP1R36 (sil: 0.44) ...

Cluster 5 (k=5)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 48 genes.
Average Silhouette Score: -0.060.
Highest expression is observed in: Liver, Cells - EBV-transformed lymphocytes, Kidney - Cortex, Small Intestine - Terminal Ileum, Lung.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Molecular_Function_2025: Solute:Sodium Symporter Activity (GO:0015370) (Adj. P: 0.010, Combined Score: 292.28) *(Total significant: 1)*

Top Genes (by silhouette):

ABCC6 (sil: 0.08), ACTR3C (sil: 0.08), SLC28A1 (sil: 0.07), ALDOB (sil: 0.07), UNC93A (sil: 0.06), SLC5A10 (sil: 0.06), SULT1C3 (sil: 0.03), RASGEF1B (sil: 0.02), SFTA2 (sil: 0.02), CD8B (sil: 0.02), SLC17A2 (sil: 0.02), CRYBG2 (sil: 0.01), ARHGAP8 (sil: 0.01), TOX3 (sil: -0.00), ST6GAL1 (sil: -0.01), OR10A6 (sil: -0.02), SAMD5 (sil: -0.02), CD82 (sil: -0.02), NCKAP5 (sil: -0.03), PPM1N (sil: -0.03) ...

Clustering with k = 13

Resolution Visualizations (k=13)

Global Heatmap Silhouette Analysis Plot Cluster Assignments (CSV) Gene Silhouette Scores (CSV)

Cluster 1 (k=13)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 45 genes.
Average Silhouette Score: 0.235.
Highest expression is observed in: Brain - Cerebellar Hemisphere, Brain - Cerebellum, Brain - Frontal Cortex (BA9), Brain - Cortex, Brain - Anterior cingulate cortex (BA24).
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Synapse (GOCC:0045202) (FDR: 0.004); Asymmetric synapse (GOCC:0032279) (FDR: 0.006); Postsynapse (GOCC:0098794) (FDR: 0.009); Axon (GOCC:0030424) (FDR: 0.016); Postsynaptic density (GOCC:0014069) (FDR: 0.034) ... *(Total significant: 6. See string_terms.csv for full list.)*
- Component: Synapse (GO:0045202) (FDR: 0.014); Neuron to neuron synapse (GO:0098984) (FDR: 0.017); Cell junction (GO:0030054) (FDR: 0.030); Intrinsic component of membrane (GO:0031224) (FDR: 0.040); Asymmetric synapse (GO:0032279) (FDR: 0.040) ... *(Total significant: 10. See string_terms.csv for full list.)*
- Function: Gated channel activity (GO:0022836) (FDR: 0.005); Ion channel activity (GO:0005216) (FDR: 0.016); Glutamate receptor activity (GO:0008066) (FDR: 0.038); Inorganic molecular entity transmembrane transporter activity (GO:0015318) (FDR: 0.038) *(Total significant: 4)*
- TISSUES: Brain (BTO:0000142) (FDR: 1.77e-05); Hippocampus (BTO:0000601) (FDR: 2.10e-04); Cerebral hemisphere (BTO:0000231) (FDR: 6.90e-04); Forebrain (BTO:0000478) (FDR: 0.002); Cerebral cortex (BTO:0000233) (FDR: 0.009) ... *(Total significant: 6. See string_terms.csv for full list.)*
- DISEASES: Cerebellar disease (DOID:2786) (FDR: 0.045) *(Total significant: 1)*
- Keyword: Alternative splicing (KW-0025) (FDR: 8.50e-04); Membrane (KW-0472) (FDR: 0.031); Ion channel (KW-0407) (FDR: 0.032); Glycoprotein (KW-0325) (FDR: 0.037); Transmembrane helix (KW-1133) (FDR: 0.037) *(Total significant: 5)*
- KEGG: Glutamatergic synapse (hsa04724) (FDR: 0.035); Nicotine addiction (hsa05033) (FDR: 0.035) *(Total significant: 2)*
- PMID: (2008) Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify connectivity constellation and drug target genes with pleiotropic effects. (PMID:18991966) (FDR: 0.042); (2015) Human cell adhesion molecules: annotated functional subtypes and overrepresentation of addiction-associated genes. (PMID:25988664) (FDR: 0.042); (2013) Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants. (PMID:23728934) (FDR: 0.042) *(Total significant: 3)*
- HPO: Temporal measurement (EFO:0000719) (FDR: 3.78e-09); Respiratory disease biomarker (EFO:0006841) (FDR: 1.24e-08); Cytokine measurement (EFO:0004873) (FDR: 8.01e-08); Cognition (EFO:0003925) (FDR: 8.52e-08); Protein measurement (EFO:0004747) (FDR: 6.32e-07) ... *(Total significant: 88. See string_terms.csv for full list.)*
- NetworkNeighborAL: Postsynaptic cell membrane, and Protein-protein interactions at synapses (CL:22977) (FDR: 3.10e-04); Transmitter-gated channel activity, and Neurexins and neuroligins (CL:22978) (FDR: 0.015) *(Total significant: 2)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Regulation of Trans-Synaptic Signaling (GO:0099177) (Adj. P: 7.58e-04, Combined Score: 564.85); Negative Regulation of Endopeptidase Activity (GO:0010951) (Adj. P: 0.017, Combined Score: 387.24); Regulation of Endopeptidase Activity (GO:0052548) (Adj. P: 0.017, Combined Score: 360.35); Regulation of Potassium Ion Transmembrane Transport (GO:1901379) (Adj. P: 0.006, Combined Score: 354.46); Heparan Sulfate Proteoglycan Metabolic Process (GO:0030201) (Adj. P: 0.017, Combined Score: 315.36) ... *(Total significant: 30. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Glutamate-Gated Calcium Ion Channel Activity (GO:0022849) (Adj. P: 0.005, Combined Score: 2207.09); Ligand-Gated Monoatomic Ion Channel Activity Involved in Regulation of Presynaptic Membrane Potential (GO:0099507) (Adj. P: 0.005, Combined Score: 976.58); Metalloendopeptidase Inhibitor Activity (GO:0008191) (Adj. P: 0.006, Combined Score: 664.11); Heparan Sulfate Sulfotransferase Activity (GO:0034483) (Adj. P: 0.006, Combined Score: 596.93); Glutamate-Gated Receptor Activity (GO:0004970) (Adj. P: 0.006, Combined Score: 493.47) ... *(Total significant: 23. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Catenin Complex (GO:0016342) (Adj. P: 0.025, Combined Score: 225.26); Ionotropic Glutamate Receptor Complex (GO:0008328) (Adj. P: 0.028, Combined Score: 171.78); Potassium Channel Complex (GO:0034705) (Adj. P: 0.025, Combined Score: 111.26); Postsynaptic Density Membrane (GO:0098839) (Adj. P: 0.034, Combined Score: 108.96); Glutamatergic Synapse (GO:0098978) (Adj. P: 0.025, Combined Score: 92.55) ... *(Total significant: 10. See enrichr_terms.csv for full list.)*
- Reactome_2022: Synaptic Adhesion-Like Molecules R-HSA-8849932 (Adj. P: 0.032, Combined Score: 336.56); HS-GAG Biosynthesis R-HSA-2022928 (Adj. P: 0.043, Combined Score: 204.59); Protein-protein Interactions At Synapses R-HSA-6794362 (Adj. P: 0.032, Combined Score: 114.98); Neuronal System R-HSA-112316 (Adj. P: 0.020, Combined Score: 66.95); Transmission Across Chemical Synapses R-HSA-112315 (Adj. P: 0.043, Combined Score: 48.49) *(Total significant: 5)*
- Human_Phenotype_Ontology: Incomplete penetrance (HP:0003829) (Adj. P: 0.019, Combined Score: 204.50) *(Total significant: 1)*
- OMIM_Disease: ataxia (Adj. P: 0.032, Combined Score: 76.91) *(Total significant: 1)*

Top Genes (by silhouette):

RGS7 (sil: 0.43), CTNNA2 (sil: 0.41), MYT1L (sil: 0.41), SEZ6L (sil: 0.40), ATCAY (sil: 0.40), HS3ST4 (sil: 0.37), CSMD1 (sil: 0.37), SLC35F3 (sil: 0.36), GABRB1 (sil: 0.35), GRIK1 (sil: 0.35), CACNA1A (sil: 0.34), DISP2 (sil: 0.34), RBFOX1 (sil: 0.33), SLC39A12 (sil: 0.33), ANKS1B (sil: 0.33), GRIA1 (sil: 0.32), NOS1AP (sil: 0.32), KCNIP4 (sil: 0.31), NDST3 (sil: 0.31), SPOCK3 (sil: 0.31) ...

Cluster 2 (k=13)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 18 genes.
Average Silhouette Score: -0.088.
Highest expression is observed in: Cells - EBV-transformed lymphocytes, Spleen, Ovary, Testis, Brain - Cerebellum.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- HPO: Mental or behavioural disorder biomarker (EFO:0006848) (FDR: 2.60e-04); Body mass index (EFO:0004340) (FDR: 0.042); Personality trait measurement (EFO:0007911) (FDR: 0.048); Visual acuity measurement (EFO:0008385) (FDR: 0.048) *(Total significant: 4)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Molecular_Function_2025: G Protein-Coupled Receptor Kinase Activity (GO:0004703) (Adj. P: 0.044, Combined Score: 1588.07); Peroxisome Proliferator Activated Receptor Binding (GO:0042975) (Adj. P: 0.044, Combined Score: 1227.64); Neurotrophin Binding (GO:0043121) (Adj. P: 0.044, Combined Score: 992.88); Fucosyltransferase Activity (GO:0008417) (Adj. P: 0.049, Combined Score: 542.71); High Voltage-Gated Calcium Channel Activity (GO:0008331) (Adj. P: 0.049, Combined Score: 435.94) *(Total significant: 5)*
- Human_Phenotype_Ontology: Decreased circulating renin level (HP:0003351) (Adj. P: 0.040, Combined Score: 828.65); Patent foramen ovale (HP:0001655) (Adj. P: 0.040, Combined Score: 615.43); Metabolic alkalosis (HP:0200114) (Adj. P: 0.040, Combined Score: 615.43); Abnormality of the right ventricle (HP:0001707) (Adj. P: 0.040, Combined Score: 542.71); Cerebral palsy (HP:0100021) (Adj. P: 0.040, Combined Score: 395.73) ... *(Total significant: 12. See enrichr_terms.csv for full list.)*
- OMIM_Disease: lymphoma (Adj. P: 0.020, Combined Score: 219.79) *(Total significant: 1)*

Top Genes (by silhouette):

CD22 (sil: 0.05), CACNA1D (sil: 0.04), CBFA2T3 (sil: -0.01), COL19A1 (sil: -0.02), MSI2 (sil: -0.03), SFMBT2 (sil: -0.03), CEP19 (sil: -0.05), FUT8 (sil: -0.07), CHCHD6 (sil: -0.09), PCSK6 (sil: -0.10), ASB3 (sil: -0.11), CCDC148 (sil: -0.11), FOCAD (sil: -0.12), ASXL3 (sil: -0.15), CCDC171 (sil: -0.18), GRK4 (sil: -0.20), TPH2 (sil: -0.20), PAX5 (sil: -0.21) ...

Cluster 3 (k=13)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 8 genes.
Average Silhouette Score: 0.054.
Highest expression is observed in: Heart - Atrial Appendage, Heart - Left Ventricle, Muscle - Skeletal, Colon - Sigmoid, Esophagus - Muscularis.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Sarcolemma (GOCC:0042383) (FDR: 0.006) *(Total significant: 1)*
- Component: Junctional sarcoplasmic reticulum membrane (GO:0014701) (FDR: 0.019); Sarcolemma (GO:0042383) (FDR: 0.019) *(Total significant: 2)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Epithelial Cell Apoptotic Process (GO:1904019) (Adj. P: 0.023, Combined Score: 4436.86); Regulation of SA Node Cell Action Potential (GO:0098907) (Adj. P: 0.023, Combined Score: 4436.86); Striated Muscle Hypertrophy (GO:0014897) (Adj. P: 0.023, Combined Score: 4436.86); Striated Muscle Cell Differentiation (GO:0051146) (Adj. P: 0.004, Combined Score: 3897.96); Cellular Response to Caffeine (GO:0071313) (Adj. P: 0.023, Combined Score: 3445.29) ... *(Total significant: 109. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: 3-hydroxyacyl-CoA Dehydratase Activity (GO:0018812) (Adj. P: 0.017, Combined Score: 3445.29); Protein Kinase A Regulatory Subunit Binding (GO:0034237) (Adj. P: 8.82e-04, Combined Score: 3250.02); Adenylate Cyclase Binding (GO:0008179) (Adj. P: 0.017, Combined Score: 2343.48); enoyl-CoA Hydratase Activity (GO:0004300) (Adj. P: 0.017, Combined Score: 1549.44); Intracellularly Ligand-Gated Monoatomic Ion Channel Activity (GO:0005217) (Adj. P: 0.017, Combined Score: 1385.98) ... *(Total significant: 13. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Junctional Sarcoplasmic Reticulum Membrane (GO:0014701) (Adj. P: 0.032, Combined Score: 2008.48); Sarcolemma (GO:0042383) (Adj. P: 0.003, Combined Score: 1143.57); Smooth Endoplasmic Reticulum (GO:0005790) (Adj. P: 0.045, Combined Score: 774.04); Sarcoplasmic Reticulum Membrane (GO:0033017) (Adj. P: 0.049, Combined Score: 417.81); Sarcoplasmic Reticulum (GO:0016529) (Adj. P: 0.049, Combined Score: 240.13) ... *(Total significant: 9. See enrichr_terms.csv for full list.)*
- Reactome_2022: Netrin Mediated Repulsion Signals R-HSA-418886 (Adj. P: 0.043, Combined Score: 2343.48); Regulation Of Commissural Axon Pathfinding By SLIT And ROBO R-HSA-428542 (Adj. P: 0.043, Combined Score: 2008.48); Role Of Second Messengers In Netrin-1 Signaling R-HSA-418890 (Adj. P: 0.043, Combined Score: 1751.86); DSCAM Interactions R-HSA-376172 (Adj. P: 0.043, Combined Score: 1549.44); DCC Mediated Attractive Signaling R-HSA-418885 (Adj. P: 0.044, Combined Score: 1138.86) *(Total significant: 5)*
- Human_Phenotype_Ontology: Right ventricular cardiomyopathy (HP:0011663) (Adj. P: 0.020, Combined Score: 2008.48); Sudden death (HP:0001699) (Adj. P: 0.020, Combined Score: 1138.86); Ventricular tachycardia (HP:0004756) (Adj. P: 0.020, Combined Score: 961.58); Syncope (HP:0001279) (Adj. P: 0.020, Combined Score: 682.33); Atrial fibrillation (HP:0005110) (Adj. P: 0.020, Combined Score: 401.40) ... *(Total significant: 12. See enrichr_terms.csv for full list.)*
- OMIM_Disease: arrhythmogenic right ventricular dysplasia (Adj. P: 0.005, Combined Score: 1251.42) *(Total significant: 1)*

Top Genes (by silhouette):

RYR2 (sil: 0.13), PEBP4 (sil: 0.11), POPDC2 (sil: 0.10), ASB2 (sil: 0.09), PDE1C (sil: 0.03), HACD1 (sil: 0.03), NTN1 (sil: 0.03), AKAP6 (sil: -0.09) ...

Cluster 4 (k=13)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 12 genes.
Average Silhouette Score: 0.127.
Highest expression is observed in: Cells - EBV-transformed lymphocytes, Cells - Cultured fibroblasts, Artery - Aorta, Brain - Cerebellar Hemisphere, Brain - Frontal Cortex (BA9).
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- TISSUES: Leukemia cell (BTO:0001271) (FDR: 0.002) *(Total significant: 1)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Cellular_Component_2025: Nuclear Envelope Lumen (GO:0005641) (Adj. P: 0.040, Combined Score: 2638.91); bBAF Complex (GO:0140092) (Adj. P: 0.040, Combined Score: 1185.99); Nuclear Inclusion Body (GO:0042405) (Adj. P: 0.040, Combined Score: 1032.95); npBAF Complex (GO:0071564) (Adj. P: 0.040, Combined Score: 815.05); Brahma Complex (GO:0035060) (Adj. P: 0.040, Combined Score: 735.02) ... *(Total significant: 9. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: UV Response Dn (Adj. P: 0.019, Combined Score: 160.22) *(Total significant: 1)*
- Human_Phenotype_Ontology: Scanning speech (HP:0002168) (Adj. P: 0.039, Combined Score: 1385.98); Cortical dysplasia (HP:0002539) (Adj. P: 0.039, Combined Score: 1385.98); Genetic anticipation (HP:0003743) (Adj. P: 0.039, Combined Score: 1385.98); Dysmetric saccades (HP:0000641) (Adj. P: 0.039, Combined Score: 1032.95); Accelerated skeletal maturation (HP:0005616) (Adj. P: 0.025, Combined Score: 898.17) ... *(Total significant: 68. See enrichr_terms.csv for full list.)*
- OMIM_Disease: breast cancer (Adj. P: 0.029, Combined Score: 275.14); obesity (Adj. P: 0.029, Combined Score: 241.48); spinocerebellar ataxia (Adj. P: 0.029, Combined Score: 192.34); ataxia (Adj. P: 0.035, Combined Score: 102.58) *(Total significant: 4)*

Top Genes (by silhouette):

YWHAB (sil: 0.28), SUB1 (sil: 0.21), PIGX (sil: 0.20), CELF2 (sil: 0.16), PKM (sil: 0.14), FAM172A (sil: 0.13), XYLT1 (sil: 0.13), FTO (sil: 0.12), ATXN1 (sil: 0.12), RB1CC1 (sil: 0.08), SMARCA2 (sil: 0.03), TUBB (sil: -0.07) ...

Cluster 5 (k=13)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 28 genes.
Average Silhouette Score: 0.028.
Highest expression is observed in: Brain - Cerebellar Hemisphere, Brain - Cerebellum, Brain - Frontal Cortex (BA9), Brain - Cortex, Brain - Anterior cingulate cortex (BA24).
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- HPO: Mental or behavioural disorder biomarker (EFO:0006848) (FDR: 8.72e-06); Temporal measurement (EFO:0000719) (FDR: 6.68e-05); Self reported educational attainment (EFO:0004784) (FDR: 2.70e-04); Protein measurement (EFO:0004747) (FDR: 3.30e-04); Mathematical ability (EFO:0004875) (FDR: 0.001) ... *(Total significant: 17. See string_terms.csv for full list.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Molecular_Function_2025: Transmembrane Receptor Protein Kinase Activity (GO:0019199) (Adj. P: 0.040, Combined Score: 293.93); Transmembrane Receptor Protein Tyrosine Kinase Activity (GO:0004714) (Adj. P: 0.040, Combined Score: 195.08); GTPase Regulator Activity (GO:0030695) (Adj. P: 0.040, Combined Score: 45.82) *(Total significant: 3)*
- Human_Phenotype_Ontology: Complete atrioventricular canal defect (HP:0001674) (Adj. P: 0.014, Combined Score: 727.05); Atrioventricular canal defect (HP:0006695) (Adj. P: 0.014, Combined Score: 528.58); Sacral dimple (HP:0000960) (Adj. P: 0.029, Combined Score: 225.26); Downturned corners of mouth (HP:0002714) (Adj. P: 0.029, Combined Score: 195.08); Triangular face (HP:0000325) (Adj. P: 0.041, Combined Score: 133.12) ... *(Total significant: 8. See enrichr_terms.csv for full list.)*

Top Genes (by silhouette):

DENND2A (sil: 0.18), CCDC149 (sil: 0.14), ZNF423 (sil: 0.14), RASGRF2 (sil: 0.13), TMEM132C (sil: 0.12), GABBR1 (sil: 0.12), THSD7A (sil: 0.07), GALNT18 (sil: 0.07), CCDC85A (sil: 0.06), SGSM2 (sil: 0.05), RERGL (sil: 0.04), AFF3 (sil: 0.04), NFIA (sil: 0.03), CNTN4 (sil: 0.02), PLCB1 (sil: 0.02), RNF150 (sil: 0.02), KAZN (sil: 0.01), NTRK3 (sil: 0.01), DDR1 (sil: 0.00), CHL1 (sil: 0.00) ...

Cluster 6 (k=13)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 37 genes.
Average Silhouette Score: 0.116.
Highest expression is observed in: Adipose - Visceral (Omentum), Liver, Adipose - Subcutaneous, Artery - Coronary, Fallopian Tube.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- HPO: Mental or behavioural disorder biomarker (EFO:0006848) (FDR: 1.30e-04); Eye disease (EFO:0003966) (FDR: 1.90e-04); Lipid measurement (EFO:0004529) (FDR: 8.50e-04); Disease (EFO:0000408) (FDR: 0.001); Lung disease (EFO:0003818) (FDR: 0.001) ... *(Total significant: 41. See string_terms.csv for full list.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Positive Regulation of Cell-Substrate Adhesion (GO:0010811) (Adj. P: 0.004, Combined Score: 402.89); Sprouting Angiogenesis (GO:0002040) (Adj. P: 0.032, Combined Score: 277.66) *(Total significant: 2)*
- GO_Molecular_Function_2025: Low-Density Lipoprotein Particle Binding (GO:0030169) (Adj. P: 0.023, Combined Score: 638.48); Lipoprotein Particle Binding (GO:0071813) (Adj. P: 0.024, Combined Score: 385.47) *(Total significant: 2)*
- GO_Cellular_Component_2025: Collagen-Containing Extracellular Matrix (GO:0062023) (Adj. P: 0.042, Combined Score: 59.28) *(Total significant: 1)*
- MSigDB_Hallmark_2020: Adipogenesis (Adj. P: 0.046, Combined Score: 45.35); Estrogen Response Early (Adj. P: 0.046, Combined Score: 45.35); Inflammatory Response (Adj. P: 0.046, Combined Score: 45.35) *(Total significant: 3)*
- OMIM_Disease: macular degeneration (Adj. P: 0.003, Combined Score: 541.47); ehlers-danlos (Adj. P: 0.040, Combined Score: 216.36); cdeficiency (Adj. P: 0.040, Combined Score: 172.65) *(Total significant: 3)*

Top Genes (by silhouette):

PARD3B (sil: 0.26), TMTC1 (sil: 0.22), LPP (sil: 0.21), SH3RF3 (sil: 0.20), C3 (sil: 0.20), ABCA1 (sil: 0.20), PTPRG (sil: 0.20), INPP4B (sil: 0.18), AAMDC (sil: 0.17), ADAMTS2 (sil: 0.16), PARM1 (sil: 0.16), UTRN (sil: 0.16), ANGPT1 (sil: 0.16), SLCO2A1 (sil: 0.16), TSKU (sil: 0.16), TLR3 (sil: 0.14), SLC25A24 (sil: 0.14), LRMDA (sil: 0.12), VIT (sil: 0.11), EEPD1 (sil: 0.11) ...

Cluster 7 (k=13)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 48 genes.
Average Silhouette Score: 0.144.
Highest expression is observed in: Cells - Cultured fibroblasts, Cells - EBV-transformed lymphocytes, Testis, Thyroid, Uterus.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- Keyword: Alternative splicing (KW-0025) (FDR: 0.021); Phosphoprotein (KW-0597) (FDR: 0.037) *(Total significant: 2)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Cellular_Component_2025: MLL1 Complex (GO:0071339) (Adj. P: 0.036, Combined Score: 187.27); MLL1/2 Complex (GO:0044665) (Adj. P: 0.036, Combined Score: 178.86); Intracellular Membrane-Bounded Organelle (GO:0043231) (Adj. P: 0.036, Combined Score: 17.83); Nucleus (GO:0005634) (Adj. P: 0.036, Combined Score: 14.44) *(Total significant: 4)*

Top Genes (by silhouette):

EHMT1 (sil: 0.32), NOP9 (sil: 0.28), SEC23IP (sil: 0.27), ZNF282 (sil: 0.26), KANSL1 (sil: 0.26), GNL3 (sil: 0.24), SCAMP3 (sil: 0.24), KLHDC4 (sil: 0.24), CYB5RL (sil: 0.24), PARS2 (sil: 0.23), TRIM26 (sil: 0.22), TMEM260 (sil: 0.22), BAG6 (sil: 0.21), UGGT1 (sil: 0.20), ZZEF1 (sil: 0.20), NCOR2 (sil: 0.20), CSE1L (sil: 0.19), PUS10 (sil: 0.19), MRPL37 (sil: 0.18), ZC3H7A (sil: 0.18) ...

Cluster 8 (k=13)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 12 genes.
Average Silhouette Score: 0.674.
Highest expression is observed in: Testis, Kidney - Medulla, Pancreas, Brain - Spinal cord (cervical c-1), Stomach.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- NetworkNeighborAL: Mixed, incl. Protein of unknown function DUF4659, and piRNA binding (CL:35645) (FDR: 0.043) *(Total significant: 1)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- Reactome_2022: Expression And Translocation Of Olfactory Receptors R-HSA-9752946 (Adj. P: 0.035, Combined Score: 38.12); Olfactory Signaling Pathway R-HSA-381753 (Adj. P: 0.035, Combined Score: 36.97) *(Total significant: 2)*

Top Genes (by silhouette):

OR5V1 (sil: 0.78), OR5AC2 (sil: 0.78), C18orf63 (sil: 0.78), C20orf173 (sil: 0.78), ACTL8 (sil: 0.76), LRRC74A (sil: 0.76), C5orf47 (sil: 0.75), C4orf45 (sil: 0.69), EFCAB5 (sil: 0.61), ZSCAN5C (sil: 0.56), ZPLD1 (sil: 0.43), PPP1R36 (sil: 0.39) ...

Cluster 9 (k=13)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 5 genes.
Average Silhouette Score: 0.441.
Highest expression is observed in: Liver, Kidney - Cortex, Small Intestine - Terminal Ileum, Kidney - Medulla, Pancreas.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- Process: Carbohydrate derivative transport (GO:1901264) (FDR: 0.013) *(Total significant: 1)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Nucleobase Transport (GO:0015851) (Adj. P: 0.008, Combined Score: 8352.53); Leukotriene Transport (GO:0071716) (Adj. P: 0.008, Combined Score: 6499.56); Fructose Metabolic Process (GO:0006000) (Adj. P: 0.008, Combined Score: 5287.72); Purine Nucleobase Transport (GO:0006863) (Adj. P: 0.009, Combined Score: 3808.55); Icosanoid Transport (GO:0071715) (Adj. P: 0.011, Combined Score: 2173.55) ... *(Total significant: 15. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: ABC-type Glutathione S-conjugate Transporter Activity (GO:0015431) (Adj. P: 0.006, Combined Score: 6499.56); Pyrimidine Nucleobase Transmembrane Transporter Activity (GO:0005350) (Adj. P: 0.006, Combined Score: 6499.56); Pyrimidine Nucleoside Transmembrane Transporter Activity (GO:0015214) (Adj. P: 0.006, Combined Score: 5287.72); Nucleoside Transmembrane Transporter Activity (GO:0005337) (Adj. P: 0.006, Combined Score: 4436.86); Urate Transmembrane Transporter Activity (GO:0015143) (Adj. P: 0.006, Combined Score: 4436.86) ... *(Total significant: 15. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Brush Border Membrane (GO:0031526) (Adj. P: 0.030, Combined Score: 589.61); Cell Projection Membrane (GO:0031253) (Adj. P: 0.040, Combined Score: 170.36); Basolateral Plasma Membrane (GO:0016323) (Adj. P: 0.049, Combined Score: 75.00) *(Total significant: 3)*
- Reactome_2022: Fructose Catabolism R-HSA-70350 (Adj. P: 0.009, Combined Score: 8352.53); LDL Remodeling R-HSA-8964041 (Adj. P: 0.009, Combined Score: 6499.56); Fructose Metabolism R-HSA-5652084 (Adj. P: 0.009, Combined Score: 5287.72); Transport Of Nucleosides And Free Purine And Pyrimidine Bases Across Plasma Membrane R-HSA-83936 (Adj. P: 0.012, Combined Score: 2638.91); Gluconeogenesis R-HSA-70263 (Adj. P: 0.021, Combined Score: 777.86) ... *(Total significant: 14. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Hypoxia (Adj. P: 0.049, Combined Score: 75.00); Glycolysis (Adj. P: 0.049, Combined Score: 75.00) *(Total significant: 2)*
- Human_Phenotype_Ontology: Hypophosphatemia (HP:0002148) (Adj. P: 0.001, Combined Score: 4898.38); Malnutrition (HP:0004395) (Adj. P: 0.015, Combined Score: 3808.55); Mitral stenosis (HP:0001718) (Adj. P: 0.015, Combined Score: 3808.55); Hypophosphatemic rickets (HP:0004912) (Adj. P: 0.015, Combined Score: 3326.77); Vascular calcification (HP:0004934) (Adj. P: 0.015, Combined Score: 3326.77) ... *(Total significant: 57. See enrichr_terms.csv for full list.)*

Top Genes (by silhouette):

SLC17A2 (sil: 0.51), SLC28A1 (sil: 0.46), LPA (sil: 0.46), ALDOB (sil: 0.42), ABCC6 (sil: 0.35) ...

Cluster 10 (k=13)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 19 genes.
Average Silhouette Score: -0.061.
Highest expression is observed in: Lung, Thyroid, Kidney - Medulla, Cells - EBV-transformed lymphocytes, Liver.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Molecular_Function_2025: D-glucose:sodium Symporter Activity (GO:0005412) (Adj. P: 0.044, Combined Score: 1147.41); Fructose Transmembrane Transporter Activity (GO:0005353) (Adj. P: 0.044, Combined Score: 774.04); Cuprous Ion Binding (GO:1903136) (Adj. P: 0.044, Combined Score: 774.04); Solute:Monoatomic Cation Symporter Activity (GO:0015294) (Adj. P: 0.044, Combined Score: 574.57); Carbohydrate:Monoatomic Cation Symporter Activity (GO:0005402) (Adj. P: 0.044, Combined Score: 574.57) ... *(Total significant: 6. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Basement Membrane (GO:0005604) (Adj. P: 0.023, Combined Score: 336.55) *(Total significant: 1)*
- Reactome_2022: Termination Of O-glycan Biosynthesis R-HSA-977068 (Adj. P: 0.019, Combined Score: 845.42) *(Total significant: 1)*
- OMIM_Disease: ciliary dyskinesia (Adj. P: 0.011, Combined Score: 451.76) *(Total significant: 1)*

Top Genes (by silhouette):

ARHGAP8 (sil: 0.04), SAMD5 (sil: 0.02), SFTA2 (sil: 0.01), FHIT (sil: -0.01), FARP1 (sil: -0.02), FRAS1 (sil: -0.03), COL4A4 (sil: -0.04), RASGEF1B (sil: -0.05), TOX3 (sil: -0.06), DNAH11 (sil: -0.08), SLC5A10 (sil: -0.08), KCNJ16 (sil: -0.08), MMAB (sil: -0.10), NCKAP5 (sil: -0.10), CH25H (sil: -0.10), COX17 (sil: -0.10), MUC16 (sil: -0.11), ACTR3C (sil: -0.12), ST6GAL1 (sil: -0.14) ...

Cluster 11 (k=13)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 7 genes.
Average Silhouette Score: 0.181.
Highest expression is observed in: Esophagus - Mucosa, Skin - Sun Exposed (Lower leg), Skin - Not Sun Exposed (Suprapubic), Vagina, Cervix - Ectocervix.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Positive Regulation of Spindle Assembly (GO:1905832) (Adj. P: 0.033, Combined Score: 4108.59); Regulation of Protein Localization to Cell Cortex (GO:1904776) (Adj. P: 0.033, Combined Score: 3338.15); Cochlea Morphogenesis (GO:0090103) (Adj. P: 0.033, Combined Score: 1497.03); Regulation of Spindle Organization (GO:0090224) (Adj. P: 0.033, Combined Score: 869.87); Positive Regulation of Filopodium Assembly (GO:0051491) (Adj. P: 0.033, Combined Score: 626.10) ... *(Total significant: 21. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: GDP-dissociation Inhibitor Activity (GO:0005092) (Adj. P: 0.032, Combined Score: 1497.03); Virus Receptor Activity (GO:0001618) (Adj. P: 0.032, Combined Score: 546.01); Cell Adhesion Mediator Activity (GO:0098631) (Adj. P: 0.032, Combined Score: 376.32); Protein Homodimerization Activity (GO:0042803) (Adj. P: 0.038, Combined Score: 43.68) *(Total significant: 4)*
- GO_Cellular_Component_2025: Cell-Cell Junction (GO:0005911) (Adj. P: 0.040, Combined Score: 133.03) *(Total significant: 1)*
- Reactome_2022: Nectin/Necl Trans Heterodimerization R-HSA-420597 (Adj. P: 0.037, Combined Score: 3338.15) *(Total significant: 1)*
- Human_Phenotype_Ontology: Cerebellar dysplasia (HP:0007033) (Adj. P: 0.018, Combined Score: 2797.66); Partial agenesis of the corpus callosum (HP:0001338) (Adj. P: 0.018, Combined Score: 1657.40); Heterotopia (HP:0002282) (Adj. P: 0.018, Combined Score: 1066.85); Polymicrogyria (HP:0002126) (Adj. P: 0.035, Combined Score: 305.55); Intellectual disability, mild (HP:0001256) (Adj. P: 0.035, Combined Score: 193.03) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*

Top Genes (by silhouette):

UNC93A (sil: 0.28), NECTIN1 (sil: 0.24), OR10A6 (sil: 0.23), LYPD5 (sil: 0.23), CRYBG2 (sil: 0.21), GPSM2 (sil: 0.08), TENM2 (sil: -0.01) ...

Cluster 12 (k=13)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 10 genes.
Average Silhouette Score: 0.225.
Highest expression is observed in: Cells - EBV-transformed lymphocytes, Whole Blood, Spleen, Lung, Skin - Not Sun Exposed (Suprapubic).
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Vesicle (GOCC:0031982) (FDR: 0.035) *(Total significant: 1)*
- Keyword: Immunity (KW-0391) (FDR: 0.050); Adaptive immunity (KW-1064) (FDR: 0.050) *(Total significant: 2)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Macropinocytosis (GO:0044351) (Adj. P: 0.028, Combined Score: 2093.27); Gamma-Delta T Cell Activation (GO:0046629) (Adj. P: 0.028, Combined Score: 1500.17); Pinocytosis (GO:0006907) (Adj. P: 0.028, Combined Score: 1307.49); Negative Regulation of Defense Response to Virus (GO:0050687) (Adj. P: 0.028, Combined Score: 932.06); Myeloid Dendritic Cell Activation (GO:0001773) (Adj. P: 0.028, Combined Score: 932.06) ... *(Total significant: 13. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Natural Killer Cell Lectin-Like Receptor Binding (GO:0046703) (Adj. P: 0.026, Combined Score: 2093.27); Neurexin Family Protein Binding (GO:0042043) (Adj. P: 0.026, Combined Score: 1307.49); MHC Class I Protein Binding (GO:0042288) (Adj. P: 0.026, Combined Score: 932.06); MHC Protein Binding (GO:0042287) (Adj. P: 0.039, Combined Score: 385.85) *(Total significant: 4)*
- GO_Cellular_Component_2025: T Cell Receptor Complex (GO:0042101) (Adj. P: 0.028, Combined Score: 776.21); Tertiary Granule Membrane (GO:0070821) (Adj. P: 0.010, Combined Score: 532.12); Exocytic Vesicle (GO:0070382) (Adj. P: 0.037, Combined Score: 335.86); Secretory Vesicle (GO:0099503) (Adj. P: 0.037, Combined Score: 308.54); Specific Granule (GO:0042581) (Adj. P: 0.016, Combined Score: 186.67) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*
- Reactome_2022: Role Of Nef In HIV-1 Replication And Disease Pathogenesis R-HSA-164952 (Adj. P: 0.004, Combined Score: 1887.30); Immunoregulatory Interactions Between A Lymphoid And A non-Lymphoid Cell R-HSA-198933 (Adj. P: 0.003, Combined Score: 748.14); Host Interactions Of HIV Factors R-HSA-162909 (Adj. P: 0.003, Combined Score: 695.56); HIV Infection R-HSA-162906 (Adj. P: 0.005, Combined Score: 325.86); Adaptive Immune System R-HSA-1280218 (Adj. P: 0.008, Combined Score: 142.03) ... *(Total significant: 8. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Interferon Alpha Response (Adj. P: 0.013, Combined Score: 360.55); p53 Pathway (Adj. P: 0.014, Combined Score: 136.48); Allograft Rejection (Adj. P: 0.014, Combined Score: 136.48); Interferon Gamma Response (Adj. P: 0.014, Combined Score: 136.48) *(Total significant: 4)*
- Human_Phenotype_Ontology: Chronic otitis media (HP:0000389) (Adj. P: 0.022, Combined Score: 1751.86); Nasal polyposis (HP:0100582) (Adj. P: 0.022, Combined Score: 1155.57); Chronic sinusitis (HP:0011109) (Adj. P: 0.022, Combined Score: 932.06); Abnormality of the nasal mucosa (HP:0000433) (Adj. P: 0.022, Combined Score: 932.06); Recurrent bronchitis (HP:0002837) (Adj. P: 0.022, Combined Score: 714.91) ... *(Total significant: 15. See enrichr_terms.csv for full list.)*
- OMIM_Disease: prostate cancer (Adj. P: 0.015, Combined Score: 321.69) *(Total significant: 1)*

Top Genes (by silhouette):

DOCK2 (sil: 0.36), PSMB9 (sil: 0.33), CD8B (sil: 0.26), SYTL3 (sil: 0.26), TAP1 (sil: 0.25), CD82 (sil: 0.21), MICB (sil: 0.17), NBEAL2 (sil: 0.17), PPM1N (sil: 0.14), LAIR1 (sil: 0.10) ...

Cluster 13 (k=13)

Gene List (TXT) Cluster Heatmap (PNG)

This cluster contains 7 genes.
Average Silhouette Score: 0.040.
Highest expression is observed in: Cells - EBV-transformed lymphocytes, Cells - Cultured fibroblasts, Testis, Small Intestine - Terminal Ileum, Colon - Transverse.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Long-Chain Fatty Acid Catabolic Process (GO:0042758) (Adj. P: 0.034, Combined Score: 3338.15); CRD-mediated mRNA Stabilization (GO:0070934) (Adj. P: 0.034, Combined Score: 2093.27); Mitotic DNA Replication (GO:1902969) (Adj. P: 0.034, Combined Score: 2093.27); Purine Ribonucleoside Bisphosphate Metabolic Process (GO:0034035) (Adj. P: 0.034, Combined Score: 1497.03); Negative Regulation of Viral Transcription (GO:0032897) (Adj. P: 0.034, Combined Score: 1362.86) ... *(Total significant: 59. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Aryl Sulfotransferase Activity (GO:0004062) (Adj. P: 0.023, Combined Score: 3338.15); N6-methyladenosine-containing RNA Reader Activity (GO:1990247) (Adj. P: 0.023, Combined Score: 1852.16); mRNA 5'-UTR Binding (GO:0048027) (Adj. P: 0.031, Combined Score: 771.89); Sulfotransferase Activity (GO:0008146) (Adj. P: 0.033, Combined Score: 416.20); Acetylglucosaminyltransferase Activity (GO:0008375) (Adj. P: 0.033, Combined Score: 364.51) *(Total significant: 5)*
- Reactome_2022: Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) Bind RNA R-HSA-428359 (Adj. P: 0.050, Combined Score: 3338.15); Unwinding Of DNA R-HSA-176974 (Adj. P: 0.050, Combined Score: 1852.16) *(Total significant: 2)*

Top Genes (by silhouette):

TPX2 (sil: 0.17), IGF2BP3 (sil: 0.09), SULT1C3 (sil: 0.04), ADTRP (sil: 0.03), GINS1 (sil: 0.01), TRIM31 (sil: -0.03), GCNT1 (sil: -0.03) ...